Endocrine Abstracts

The clinical condition resulting from end-organ resistance to parathormone (rPTH), caused by (epi)genetic alterations of GNAS, was termed as Pseudohypoparathyroidism (PHP). The high phenotype heterogeneity, the existence of additional clinical features such as resistance to other hormones (TSH/GHRH/gonadotropins) and Albright’s hereditary osteodystrophy (AHO), led to the distinction of specific PHP subtypes.The purpose of the present work is to prov...

Introduction: Craniofacial fibrous dysplasia, characteristic of McCune-Albright syndrome (MAS), is usually present in patients with MAS related GH excess, and complicates their neurosurgical approach. We describe a 21-year-old male with severe craniofacial fibrous dysplasia and acute obstructive hydrocephalus due to a 39×35 mm cystic lesion in the third ventricle that occluded Monro’s foramina, in whom MAS and long-term untreated acromegaly were discovered.<p cla...